When you hear the word coenzyme Q10, or CoQ10, you’ll most likely hear it used alongside two other words: ubiquinone and ubiquinol. These unfamiliar words may sound confusing at first, but soon enough, you’ll appreciate how they all fit together.
Here is the easiest way to understand this potent coenzyme:
- Coenzyme Q10, a vitamin-like substance, comes in two different forms.
- Ubiquinone is the fully oxidised form of CoQ10 that is metabolised by the body.
- Ubiquinol is produced as the antioxidant form of CoQ10 through this metabolism of ubiquinone.
There is another piece of the puzzle. With age, natural CoQ10 levels in the body begin to decline, and it also becomes harder for the body to convert CoQ10 into essential ubiquinol. Lipids researchers found that ubiquinone levels, or oxidised coenzyme Q1O in the body, peaked in many organs at 20 years of age, followed by a continuous decline each year after. 1 The body relies on a daily dose of CoQ10 to strengthen the heart, while cholesterol-lowering statin drugs have a counterintuitive effect and can lower CoQ10 levels even further. 2
As you begin to understand how CoQ10 benefits the body, it becomes clear what a devastating problem age-related CoQ10 depletion can be. The European Society of Cardiology made a major discovery in 2013 that changed how the world sees this vital nutrient. CoQ10 taken as a supplement was proven to be the first ‘drug to decrease heart failure mortality in more than a decade – by 50 per cent. Based on these compelling study results presented at the Heart Failure Congress 2013, lead author Professor Svend Aage Mortensen now recommends the coenzyme as a standard mode of heart failure treatment. 3
Just a year later, CoQ10 was proven to be a powerful dietary supplement to help veterans suffering from symptoms of Gulf War illness, which included muscle pain, fatigue, digestive troubles and decreased cognitive function. 80 per cent of veterans who took coenzyme Q10 to treat Gulf War illness, thought to be caused by chemical exposure, saw an improvement in physical function at only 100 mg per day. 4 CoQ10’s protective ability to reduce oxidative damage at the cellular level may also prove promising in slowing Huntington’s disease, a genetic neurodegenerative disorder that can progress to affect cognition, behaviour, and movement and may cause death within 20 years. 5
2 BIG PROBLEMS WITH COQ10
Most people will see a decline in health because of a lack of CoQ10, and there are two reasons why:
- CoQ10 levels have fallen dangerously low.
- A CoQ10 supplement is being taken in the wrong form.
As we already mentioned, coenzyme QIO levels start to rapidly decrease at the age of 20, a time when many young people don’t think about taking a protective antioxidant supplement. Dr Stephen Sinatra, author of The Coenzyme Q10 Phenomenon, estimates that a drop in CoQ10 becomes serious enough to impair organ function when levels in the body fall by just 25 per cent. CoQ10 levels that decrease by 75 per cent could cause irreparable tissue damage or even death. 6
The only way to prevent this dangerous landslide is to talce a daily CoQ10 supplement. The lion’s share of over-thecounter coenzyme Q10 supplements are marketed in the wrong form. Taking standard CoQ10, or ubiquinone, is not enough. Ubiquinol is the form of CoQ10 that is eight times better absorbed compared to ordinary CoQ10.
A highly absorbable ubiquinol supplement solves these problems immediately — by making it easy for your body to replenish a vital antioxidant in a form it can use.
A coenzyme Q10 that is X8 better absorbed compared to ordinary CoQ10. Derived from KanekaQ10, the world’s most researched and recognised Q10. Delivered in gelatin softgel.
- Kalén, A, Appelkvist, E L and Dallner, G. (1989) Age-related changes in the lipid compositions of .rat and human tissues. Lipids. 24 (7) pp. 579-84.
- Deichmann, R.,Lavie, C and Andrews, S. (2010) Coenzyme q10 and statin-induced mitochondrial dysfunction. Oschner J., 10(1) pp 16-21.
- Mortensen, S. A., Kumar, A. Doliner, P et al (2013). The effect of Coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. Presented at Heart Failure Congress 2013 Final Programme Number 440.
- Golomb, B A, Allison, M. Koperski, Koslik, H. Devaraj, S. and Ritchie J. B, 2014. Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study Neural Computation, 26 (11): 25494.
- Biglan, K M., Dorsey, E. R., Evans, R V V, Ross, C A, Hersch, Sy Shoulson, L, Matson W. and Kieburtz K (2012) Plasma 8-hydroxy-2 ‘-deoxyguanosine levels in Huntingdon Disease and Healthy Controls Treated with Coenzyme Q10. Journal of Huntingdon’s Disease (1) pp. 65-9.
- Sinatra, S. T The Coenzyme QIO Phenomenon Los Angeles Lowell House, 1998. Print.